RASGRP1 anticorps (AA 594-716)

N° du produit ABIN7167163

Détail du produit anti-RASGRP1 anticorps

Antigène: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Épitope: AA 594-716

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RASGRP1 est non-conjugé

Application: ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human RAS guanyl-releasing protein 1 protein (594-716AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RASGRP1

Antigène: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Autre désignation: RASGRP1 (RASGRP1 Produits)

Synonymes: anticorps Rasgrp, anticorps CALDAG-GEFI, anticorps CALDAG-GEFII, anticorps RASGRP, anticorps V, anticorps hRasGRP1, anticorps RAS guanyl releasing protein 1, anticorps Rasgrp1, anticorps RASGRP1

Sujet:

Background: Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).

Aliases: RASGRP1 antibody, RASGRPRAS guanyl-releasing protein 1 antibody, Calcium and DAG-regulated guanine nucleotide exchange factor II antibody, CalDAG-GEFII antibody, Ras guanyl-releasing protein antibody

UniProt: O95267

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway