RAC1 anticorps (AA 11-185)

N° du produit ABIN7167196

Détail du produit anti-RAC1 anticorps

Antigène: RAC1

Épitope: AA 11-185

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAC1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Ras-related C3 botulinum toxin substrate 1 protein (11-185AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:100-1:1200, IF:1:200-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RAC1

Antigène: RAC1

Abstract: RAC1 Produits

Sujet:

Background: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2, this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.

Aliases: Cell migration inducing gene 5 protein antibody, Cell migration-inducing gene 5 protein antibody, MGC111543 antibody, MIG5 antibody, Migration inducing gene 5 antibody, Migration inducing protein 5 antibody, p21 Rac1 antibody, p21-Rac1 antibody, Rac 1 antibody, RAC1 antibody, RAC1_HUMAN antibody, Ras like protein TC25 antibody, Ras related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) antibody, Ras-like protein TC25 antibody, Ras-related C3 botulinum toxin substrate 1 antibody, Rho family small GTP binding protein Rac1 antibody, TC 25 antibody, TC25 antibody

UniProt: P63000

Pathways: Signalisation WNT, Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Thromboxane A2 Receptor Signaling, VEGF Signaling