RAB7A anticorps (AA 110-177)

N° du produit ABIN7167377

Détail du produit anti-RAB7A anticorps

Antigène: RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))

Épitope: AA 110-177

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAB7A est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Ras-related protein Rab-7a protein (110-177AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RAB7A

Antigène: RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))

Autre désignation: RAB7A (RAB7A Produits)

Synonymes: anticorps RAB5, anticorps PRO2706, anticorps RAB7, anticorps Rab7, anticorps rab7, anticorps pro2706, anticorps RAB7A, anticorps LOC100231734, anticorps ARABIDOPSIS RAB GTPASE HOMOLOG G2, anticorps ATRAB7A, anticorps ATRABG2, anticorps F7D8.20, anticorps F7D8_20, anticorps RAB GTPase homolog 7A, anticorps DDBDRAFT_0190210, anticorps DDBDRAFT_0191507, anticorps DDB_0190210, anticorps DDB_0191507, anticorps Rab7a, anticorps rab-7, anticorps zgc:64058, anticorps RAB5A, member RAS oncogene family, anticorps RAB7A, member RAS oncogene family, anticorps RAB7A, member RAS oncogene family L homeolog, anticorps rab7A protein, anticorps RAB GTPase homolog 7A, anticorps Rab GTPase, anticorps ras-related protein rab-7a, anticorps RAB7, member RAS oncogene family, anticorps RAB5A, anticorps RAB7A, anticorps Rab7a, anticorps rab7a.L, anticorps rab7a, anticorps rab7A, anticorps Rab7, anticorps rab7

Sujet:

Background: Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Aliases: CMT2B antibody, PRO2706 antibody, PSN antibody, RAB7, member RAS oncogene family antibody, RAB7A antibody, RAB7A, member RAS oncogene family antibody, RAB7A_HUMAN antibody, Ras associated protein RAB7 antibody, Ras related protein Rab7 antibody, Ras related protein Rab7a antibody, Ras-related protein Rab-7a antibody

UniProt: P51149

Pathways: EGFR Signaling Pathway, Maintenance of Protein Location, SARS-CoV-2 Protein Interactome