FIP200 anticorps (AA 1544-1594)

N° du produit ABIN7167417

Détail du produit anti-FIP200 anticorps

Antigène: FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))

Épitope: AA 1544-1594

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FIP200 est non-conjugé

Application: ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human RB1-inducible coiled-coil protein 1 protein (1544-1594AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FIP200

Antigène: FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))

Autre désignation: RB1CC1 (RB1CC1 Produits)

Synonymes: anticorps DKFZp459E2330, anticorps CC1, anticorps FIP200, anticorps 2900055E04Rik, anticorps 5930404L04Rik, anticorps Cc1, anticorps LaXp180, anticorps RB1 inducible coiled-coil 1, anticorps RB1 inducible coiled-coil 1 L homeolog, anticorps RB1-inducible coiled-coil 1, anticorps RB1CC1, anticorps rb1cc1.L, anticorps rb1cc1, anticorps Rb1cc1

Sujet:

Background: Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways.

Aliases: FAK family kinase-interacting protein of 200 kDa antibody, FIP200 antibody, RB1-inducible coiled-coil protein 1 antibody, RB1CC1 antibody, RBCC1_HUMAN antibody

UniProt: Q8TDY2

Pathways: Regulation of Cell Size, Autophagy