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RGMA anticorps (AA 153-408) (HRP)

RGMA Reactivité: Humain ELISA Hôte: Lapin Polyclonal HRP
N° du produit ABIN7167712
  • Antigène Voir toutes RGMA Anticorps
    RGMA (RGM Domain Family, Member A (RGMA))
    Épitope
    • 13
    • 7
    • 5
    • 1
    • 1
    • 1
    AA 153-408
    Reactivité
    • 23
    • 4
    • 3
    • 1
    • 1
    Humain
    Hôte
    • 22
    • 1
    Lapin
    Clonalité
    • 21
    • 2
    Polyclonal
    Conjugué
    • 10
    • 4
    • 3
    • 2
    • 2
    • 2
    Cet anticorp RGMA est conjugé à/à la HRP
    Application
    • 20
    • 19
    • 2
    • 1
    • 1
    • 1
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Repulsive guidance molecule A protein (153-408AA)
    Isotype
    IgG
    Top Product
    Discover our top product RGMA Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    RGMA (RGM Domain Family, Member A (RGMA))
    Autre désignation
    RGMA (RGMA Produits)
    Synonymes
    anticorps RGM, anticorps BC059072, anticorps C230063O06, anticorps repulsive guidance molecule family member a, anticorps repulsive guidance molecule family member A, anticorps RGMA, anticorps Rgma
    Sujet

    Background: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

    Aliases: Repulsive guidance molecule A antibody, RGM antibody, RGM domain family member A antibody, RGMA antibody, RGMA_HUMAN antibody

    UniProt
    Q96B86
    Pathways
    Tube Formation
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