p107 anticorps (AA 201-500) (HRP)
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- Antigène Voir toutes p107 (RBL1) Anticorps
- p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))
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Épitope
- AA 201-500
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp p107 est conjugé à/à la HRP
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Application
- ELISA
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human Retinoblastoma-like protein 1 protein (201-500AA)
- Isotype
- IgG
- Top Product
- Discover our top product RBL1 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))
- Autre désignation
- RBL1 (RBL1 Produits)
- Synonymes
- anticorps p107, anticorps prb1, anticorps fj58e06, anticorps wu:fj58e06, anticorps CP107, anticorps PRB1, anticorps AW547426, anticorps retinoblastoma-like 1 L homeolog, anticorps RB transcriptional corepressor like 1, anticorps retinoblastoma-like 1 (p107), anticorps retinoblastoma-like 1, anticorps rbl1.L, anticorps RBL1, anticorps rbl1, anticorps Rbl1
- Sujet
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Background: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 \'Lys-20\' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
Aliases: 107 kDa retinoblastoma-associated protein antibody, Cellular protein 107 antibody, Cellular protein p107 antibody, CP107 antibody, MGC40006 antibody, p107 antibody, PRB1 antibody, RBL1 antibody, RBL1_HUMAN antibody, Retinoblastoma like protein 1 antibody, retinoblastoma-like 1 (p107) antibody, Retinoblastoma-like protein 1 antibody
- UniProt
- P28749
- Pathways
- Cycle Cellulaire, Mitotic G1-G1/S Phases
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