p130 anticorps (AA 417-616)

N° du produit ABIN7167791

Détail du produit anti-p130 anticorps

Antigène: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Épitope: AA 417-616

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp p130 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Retinoblastoma-like protein 2 protein (417-616AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:200-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur p130

Antigène: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Autre désignation: RBL2 (RBL2 Produits)

Synonymes: anticorps RBL2, anticorps RBR2, anticorps RRB2a, anticorps PRB2, anticorps RBR-2, anticorps Rb2, anticorps p130, anticorps P130, anticorps retinoblastoma-like 2 (p130), anticorps RB transcriptional corepressor like 2, anticorps related to retinoblastoma 2, anticorps RBL2, anticorps LOC541652, anticorps Rbl2

Sujet:

Background: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 \'Lys-20\' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Aliases: 130 kDa retinoblastoma associated protein antibody, 130 kDa retinoblastoma-associated protein antibody, IB4 antibody, p130 antibody, PPAR-alpha-interacting complex protein 128 antibody, PRB2 antibody, Rb2 antibody, Rbl2 antibody, RBL2_HUMAN antibody, RBR 2 antibody, RBR-2 antibody, RBR2 antibody, Retinoblastoma like 2 antibody, Retinoblastoma-like protein 2 antibody, Retinoblastoma-related protein 2 antibody, RIC128 antibody

UniProt: Q08999

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases