PTTG1 anticorps (AA 2-202)

N° du produit ABIN7168744

Détail du produit anti-PTTG1 anticorps

Antigène: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Épitope: AA 2-202

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTTG1 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Securin protein (2-202AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PTTG1

Antigène: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Autre désignation: PTTG1 (PTTG1 Produits)

Synonymes: anticorps EAP1, anticorps HPTTG, anticorps PTTG, anticorps TUTR1, anticorps PTTG1, anticorps securin, anticorps AW555095, anticorps C87862, anticorps Pttg, anticorps Pttg3, anticorps Securin, anticorps Protein Cut2, anticorps pituitary tumor-transforming 1, anticorps pituitary tumor-transforming gene 1, anticorps securin, sister chromatid separation inhibitor, anticorps PTTG1, anticorps Pttg1, anticorps cut2

Sujet:

Background: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

Aliases: AW555095 antibody, C87862 antibody, Cut2 antibody, EAP 1 antibody, EAP1 antibody, ESP1 associated protein 1 antibody, Esp1-associated protein antibody, hPTTG antibody, MGC126883 antibody, MGC138276 antibody, Pds1 antibody, Pituitary tumor transforming 1 antibody, Pituitary tumor transforming protein 1 antibody, Pituitary tumor-transforming 1, isoform CRA_a antibody, Pituitary tumor-transforming 1, isoform CRA_b antibody, Pituitary tumor-transforming gene 1 antibody, Pituitary tumor-transforming gene 1 protein antibody, PTTG 1 antibody, PTTG antibody, PTTG1 antibody, PTTG1 protein antibody, PTTG1_HUMAN antibody, Pttg3 antibody, Securin antibody, Tumor transforming 1 antibody, Tumor transforming protein 1 antibody, Tumor-transforming protein 1 antibody, TUTR 1 antibody, TUTR1 antibody

UniProt: O95997