HTRA1 anticorps (AA 23-248)

N° du produit ABIN7168916

Détail du produit anti-HTRA1 anticorps

Antigène: HTRA1 (HtrA Serine Peptidase 1 (HTRA1))

Épitope: AA 23-248

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HTRA1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Serine protease HTRA1 protein (23-248AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur HTRA1

Antigène: HTRA1 (HtrA Serine Peptidase 1 (HTRA1))

Autre désignation: HTRA1 (HTRA1 Produits)

Synonymes: anticorps htra1, anticorps zgc:92029, anticorps zgc:172061, anticorps l56, anticorps htra, anticorps Xhtra1, anticorps prss11, anticorps MGC145723, anticorps ARMD7, anticorps CARASIL, anticorps HtrA, anticorps L56, anticorps ORF480, anticorps PRSS11, anticorps AI429470, anticorps HTRA, anticorps Prss11, anticorps RSPP11, anticorps HTRA1, anticorps HtrA serine peptidase 1a, anticorps HtrA serine peptidase 1, anticorps HtrA serine peptidase 1b, anticorps Serine protease HTRA1, anticorps HtrA serine peptidase 1 S homeolog, anticorps htra1a, anticorps HTRA1, anticorps htra1b, anticorps htra1, anticorps Htra1, anticorps htra1.S

Sujet:

Background: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

Aliases: ARMD7 antibody, CARASIL antibody, High-temperature requirement A serine peptidase 1 antibody, HtrA antibody, HtrA serine peptidase 1 antibody, HTRA1 antibody, HTRA1_HUMAN antibody, IGFBP5 protease antibody, L56 antibody, ORF480 antibody, Protease serine 11 (IGF binding) antibody, protease serine 11 antibody, PRSS11 antibody, Serine protease 11 antibody, Serine protease HTRA1 antibody, Serine protease HTRA1 precursor antibody

UniProt: Q92743

Pathways: Growth Factor Binding