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PAK4 anticorps (AA 1-426)

PAK4 Reactivité: Humain WB, ELISA, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7169132
  • Antigène Voir toutes PAK4 Anticorps
    PAK4 (P21-Activated Kinase 4 (PAK4))
    Épitope
    • 13
    • 9
    • 8
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-426
    Reactivité
    • 85
    • 54
    • 35
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 79
    • 5
    • 1
    Lapin
    Clonalité
    • 80
    • 5
    Polyclonal
    Conjugué
    • 41
    • 7
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PAK4 est non-conjugé
    Application
    • 69
    • 36
    • 19
    • 19
    • 9
    • 8
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
     Réactivité croisée
    Humain, Rat
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Serine/threonine-protein kinase PAK 4 protein (1-426AA)
    Isotype
    IgG
    Top Product
    Discover our top product PAK4 Anticorps primaire
  • Indications d'application
    Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:200-1:500,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    PAK4 (P21-Activated Kinase 4 (PAK4))
    Autre désignation
    PAK4 (PAK4 Produits)
    Synonymes
    anticorps 5730488L07Rik, anticorps AW555722, anticorps mKIAA1142, anticorps im:5916170, anticorps wu:fd12b01, anticorps zgc:92014, anticorps p21 (RAC1) activated kinase 4, anticorps p21 protein (Cdc42/Rac)-activated kinase 4, anticorps PAK4, anticorps Pak4, anticorps pak4
    Sujet

    Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.

    Aliases: KIAA1142 antibody, p21 activated kinase 4 antibody, p21 Cdc42/Rac1-actiated kinase 4 antibody, P21 protein (Cdc42/Rac) activated kinase 4 antibody, p21(CDKN1A) activated kinase 4 antibody, p21-activated kinase 4 antibody, PAK 4 antibody, PAK-4 antibody, Pak4 antibody, PAK4_HUMAN antibody, Protein kinase related to S.cerevisiae STE20 effector for Cdc42Hs antibody, Serine threonine kinase PAK 4 antibody, Serine/threonine protein kinase PAK 4 antibody, Serine/threonine protein kinase PAK4 antibody, Serine/threonine-protein kinase PAK 4 antibody

    UniProt
    O96013
    Pathways
    Signalisation RTK
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