SIK1 anticorps (AA 492-750)

N° du produit ABIN7169181

Détail du produit anti-SIK1 anticorps

Antigène: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Épitope: AA 492-750

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIK1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Serine/threonine-protein kinase SIK1 protein (492-750AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SIK1

Antigène: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Autre désignation: SIK1 (SIK1 Produits)

Synonymes: anticorps Msk, anticorps Sik, anticorps Snf1lk, anticorps SIK2, anticorps SNF1LK, anticorps MSK, anticorps SIK, anticorps salt-inducible kinase 1, anticorps salt inducible kinase 1, anticorps SIK1, anticorps Sik1

Sujet:

Background: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction, represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).

Aliases: KID2 antibody, MSK antibody, myocardial SNF1 like kinase antibody, QIK antibody, Qin-induced kinase antibody, Salt inducible kinase 1 antibody, Salt-inducible protein kinase 1 antibody, Serine threonine protein kinase SNF1 like kinase 1 antibody, Serine threonine protein kinase SNF1LK antibody, Serine/threonine-protein kinase SIK1 antibody, Serine/threonine-protein kinase SNF1-like kinase 1 antibody, Serine/threonine-protein kinase SNF1LK antibody, SIK-1 antibody, SIK1 antibody, SIK1_HUMAN antibody, SNF1 like kinase antibody, Snf1lk antibody

UniProt: P57059

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process