WNK1 anticorps (AA 1-207)

N° du produit ABIN7169222

Détail du produit anti-WNK1 anticorps

Antigène: WNK1 (WNK Lysine Deficient Protein Kinase 1 (WNK1))

Épitope: AA 1-207

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WNK1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Serine/threonine-protein kinase WNK1 protein (1-207AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur WNK1

Antigène: WNK1 (WNK Lysine Deficient Protein Kinase 1 (WNK1))

Autre désignation: WNK1 (WNK1 Produits)

Synonymes: anticorps HSAN2, anticorps HSN2, anticorps KDP, anticorps PRKWNK1, anticorps PSK, anticorps p65, anticorps WNK1, anticorps kdp, anticorps psk, anticorps hsn2, anticorps hsan2, anticorps pha2c, anticorps prkwnk1, anticorps 6430573H23Rik, anticorps EG406236, anticorps Hsn2, anticorps Prkwnk1, anticorps mKIAA0344, anticorps ATWNK1, anticorps T9J14.14, anticorps T9J14_14, anticorps ZIK4, anticorps with no lysine (K) kinase 1, anticorps WNK lysine deficient protein kinase 1, anticorps WNK lysine deficient protein kinase 1 L homeolog, anticorps serine/threonine-protein kinase WNK1, anticorps with no lysine (K) kinase 1, anticorps WNK1, anticorps wnk1.L, anticorps wnk1, anticorps LOC100056745, anticorps Wnk1

Sujet:

Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).

Aliases: Erythrocyte 65 kDa protein antibody, HSAN2 antibody, HSN2 antibody, hWNK1 antibody, KDP antibody, KIAA0344 antibody, Kinase deficient protein antibody, MGC163339 antibody, MGC163341 antibody, p65 antibody, PPP1R167 antibody, PRKWNK1 antibody, Prostate derived sterile 20 like kinase antibody, Protein kinase lysine deficient 1 antibody, Protein kinase lysine-deficient 1 antibody, Protein kinase with no lysine 1 antibody, Protein phosphatase 1, regulatory subunit 167 antibody, PSK antibody, Serine/threonine protein kinase WNK1 1 antibody, Serine/threonine protein kinase WNK1 2 antibody, Serine/threonine protein kinase WNK1 antibody, Serine/threonine-protein kinase WNK1 antibody, With no K antibody, WNK lysine deficient protein kinase 1 antibody, WNK lysine deficient protein kinase 1 isoform antibody, WNK1 antibody, WNK1_HUMAN antibody

UniProt: Q9H4A3