SESN1 anticorps (AA 224-337)

N° du produit ABIN7169405

Détail du produit anti-SESN1 anticorps

Antigène: SESN1 (Sestrin 1 (SESN1))

Épitope: AA 224-337

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SESN1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Sestrin-1 protein (224-337AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SESN1

Antigène: SESN1 (Sestrin 1 (SESN1))

Autre désignation: SESN1 (SESN1 Produits)

Synonymes: anticorps zgc:91970, anticorps sestrin-1, anticorps SESN1, anticorps XPA26, anticorps pa26, anticorps sest1, anticorps PA26, anticorps SEST1, anticorps 1110002G11Rik, anticorps AU044290, anticorps Pa26, anticorps Sest1, anticorps sesn1-A, anticorps sestrin 1, anticorps sestrin 1 L homeolog, anticorps SESN1, anticorps sesn1, anticorps Sesn1, anticorps sesn1.L

Sujet:

Background: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity).

Aliases: 1110002G11Rik antibody, AU044290 antibody, MGC118148 antibody, MGC138241 antibody, MGC142129 antibody, OTTMUSP00000022799 antibody, p53 activated gene 26 antibody, p53 regulated PA26 nuclear protein antibody, p53 regulated protein PA26 antibody, p53-regulated protein PA26 antibody, PA26 antibody, RP11-787I22.1 antibody, sesn1 antibody, SESN1_HUMAN antibody, SEST1 antibody, sestrin 1 antibody, Sestrin-1 antibody

UniProt: Q9Y6P5