SPPL2A anticorps (AA 26-172) (Biotin)

N° du produit ABIN7169624

Détail du produit anti-SPPL2A anticorps (Biotin)

Antigène: SPPL2A (Signal Peptide Peptidase-Like 2A (SPPL2A))

Épitope: AA 26-172

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPPL2A est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Signal peptide peptidase-like 2A protein (26-172AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SPPL2A

Antigène: SPPL2A (Signal Peptide Peptidase-Like 2A (SPPL2A))

Autre désignation: SPPL2A (SPPL2A Produits)

Synonymes: anticorps RGD1563001, anticorps SPPL2A, anticorps LOC453430, anticorps LOC100231183, anticorps IMP3, anticorps PSL2, anticorps 2010106G01Rik, anticorps C130089K23Rik, anticorps signal peptide peptidase-like 2A, anticorps signal peptide peptidase like 2A, anticorps Signal peptide peptidase-like 2A, anticorps Sppl2a, anticorps SPPL2A, anticorps sppl2a, anticorps psl2

Sujet:

Background: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).

Aliases: SPPL2A antibody, IMP3 antibody, PSL2 antibody, PSEC0147 antibody, Signal peptide peptidase-like 2A antibody, SPP-like 2A antibody, SPPL2a antibody, EC 3.4.23.- antibody, Intramembrane protease 3 antibody, IMP-3 antibody, Presenilin-like protein 2 antibody

UniProt: Q8TCT8