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SPPL2A anticorps (AA 26-172) (Biotin)

SPPL2A Reactivité: Humain ELISA Hôte: Lapin Polyclonal Biotin
N° du produit ABIN7169624
  • Antigène Voir toutes SPPL2A Anticorps
    SPPL2A (Signal Peptide Peptidase-Like 2A (SPPL2A))
    Épitope
    • 7
    • 4
    • 2
    • 2
    • 1
    AA 26-172
    Reactivité
    • 16
    • 1
    • 1
    Humain
    Hôte
    • 14
    • 2
    Lapin
    Clonalité
    • 15
    • 1
    Polyclonal
    Conjugué
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    Cet anticorp SPPL2A est conjugé à/à la Biotin
    Application
    • 13
    • 13
    • 10
    • 1
    • 1
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Signal peptide peptidase-like 2A protein (26-172AA)
    Isotype
    IgG
    Top Product
    Discover our top product SPPL2A Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    SPPL2A (Signal Peptide Peptidase-Like 2A (SPPL2A))
    Autre désignation
    SPPL2A (SPPL2A Produits)
    Synonymes
    anticorps RGD1563001, anticorps SPPL2A, anticorps LOC453430, anticorps LOC100231183, anticorps IMP3, anticorps PSL2, anticorps 2010106G01Rik, anticorps C130089K23Rik, anticorps signal peptide peptidase-like 2A, anticorps signal peptide peptidase like 2A, anticorps Signal peptide peptidase-like 2A, anticorps Sppl2a, anticorps SPPL2A, anticorps sppl2a, anticorps psl2
    Sujet

    Background: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).

    Aliases: SPPL2A antibody, IMP3 antibody, PSL2 antibody, PSEC0147 antibody, Signal peptide peptidase-like 2A antibody, SPP-like 2A antibody, SPPL2a antibody, EC 3.4.23.- antibody, Intramembrane protease 3 antibody, IMP-3 antibody, Presenilin-like protein 2 antibody

    UniProt
    Q8TCT8
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