Sortilin 1 anticorps (AA 328-457)

N° du produit ABIN7170335

Détail du produit anti-Sortilin 1 anticorps

Antigène: Sortilin 1 (SORT1)

Épitope: AA 328-457

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sortilin 1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Sortilin protein (328-457AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:500-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Sortilin 1

Antigène: Sortilin 1 (SORT1)

Autre désignation: SORT1 (SORT1 Produits)

Synonymes: anticorps SORT1, anticorps 19.m02079, anticorps gp95, anticorps ldlcq6, anticorps sortilin, anticorps Gp95, anticorps LDLCQ6, anticorps NT3, anticorps 2900053A11Rik, anticorps AI852375, anticorps Ntr3, anticorps Ntsr3, anticorps Nt3, anticorps Nts3, anticorps sort1, anticorps zgc:85953, anticorps sortilin 1, anticorps sortilin, anticorps sortilin 1 S homeolog, anticorps sortilin 1a, anticorps SORT1, anticorps TP01_0016, anticorps BBOV_I002730, anticorps sort1.S, anticorps Sort1, anticorps sort1a

Sujet:

Background: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.

Aliases: 100 kDa NT receptor antibody, Glycoprotein 95 antibody, Gp 95 antibody, Gp95 antibody, LDLCQ6 antibody, Neurotensin receptor 3 antibody, NT 3 antibody, NT3 antibody, NTR 3 antibody, NTR3 antibody, OTTHUMP00000013784 antibody, SORT 1 antibody, SORT_HUMAN antibody, SORT1 (gene name) antibody, Sort1 antibody, Sortilin 1 antibody, Sortilin antibody

UniProt: Q99523

Pathways: Neurotrophin Signaling Pathway