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FAM33A anticorps (AA 1-121) (Biotin)

FAM33A Reactivité: Humain ELISA Hôte: Lapin Polyclonal Biotin
N° du produit ABIN7170592
  • Antigène Voir toutes FAM33A Anticorps
    FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))
    Épitope
    • 10
    • 8
    • 6
    • 3
    • 1
    • 1
    AA 1-121
    Reactivité
    • 22
    • 3
    Humain
    Hôte
    • 22
    Lapin
    Clonalité
    • 22
    Polyclonal
    Conjugué
    • 10
    • 3
    • 3
    • 2
    • 2
    • 2
    Cet anticorp FAM33A est conjugé à/à la Biotin
    Application
    • 18
    • 17
    • 15
    • 5
    • 2
    • 1
    • 1
    • 1
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Spindle and kinetochore-associated protein 2 protein (1-121AA)
    Isotype
    IgG
    Top Product
    Discover our top product FAM33A Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))
    Autre désignation
    SKA2 (FAM33A Produits)
    Synonymes
    anticorps FAM33A, anticorps 1110001A07Rik, anticorps C78640, anticorps Fam33a, anticorps RGD1307084, anticorps fam33a, anticorps spindle and kinetochore associated complex subunit 2, anticorps Spindle and kinetochore-associated protein 2, anticorps SKA2, anticorps Ska2, anticorps ska2
    Sujet

    Background: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).

    Aliases: FAM33A antibody, Family with sequence similarity 33, member A antibody, FLJ12758 antibody, MGC110975 antibody, Protein FAM33A antibody, SKA 2 antibody, SKA2 antibody, SKA2_HUMAN antibody, Spindle and kinetochore associated complex subunit 2 antibody, Spindle and kinetochore associated protein 2 antibody, Spindle and kinetochore-associated protein 2 antibody, Spindle and KT (kinetochore) associated 2 antibody, Spindle and KT associated 2 antibody

    UniProt
    Q8WVK7
    Pathways
    M Phase
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