Spartan anticorps (AA 1-239) (HRP)

N° du produit ABIN7170653

Détail du produit anti-Spartan anticorps (HRP)

Antigène: Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))

Épitope: AA 1-239

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Spartan est conjugé à/à la HRP

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human SprT-like domain-containing protein Spartan protein (1-239AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Spartan

Antigène: Spartan (C1orf124) (Chromosome 1 Open Reading Frame 124 (C1orf124))

Autre désignation: SPRTN (C1orf124 Produits)

Synonymes: anticorps Spartan, anticorps c1orf124, anticorps C1orf124, anticorps DDDL1880, anticorps DVC1, anticorps PRO4323, anticorps dJ876B10.3, anticorps C28H1orf124, anticorps SprT-like N-terminal domain, anticorps sprtn, anticorps SPRTN

Sujet:

Background: Regulator of UV-induced DNA damage response: acts as a \'reader\' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.

Aliases: SPRTN antibody, C1orf124 antibody, DVC1 antibody, UNQ1880/PRO4323 antibody, SprT-like domain-containing protein Spartan antibody, DNA damage protein targeting VCP antibody, DVC1 antibody, Protein with SprT-like domain at the N terminus antibody, Spartan antibody

UniProt: Q9H040