SMC5 anticorps (AA 296-403) (Biotin)

N° du produit ABIN7170871

Détail du produit anti-SMC5 anticorps (Biotin)

Antigène: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Épitope: AA 296-403

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMC5 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Structural maintenance of chromosomes protein 5 protein (296-403AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SMC5

Antigène: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Autre désignation: SMC5 (SMC5 Produits)

Synonymes: anticorps F1N13.60, anticorps F1N13_60, anticorps structural maintenance of chromosomes 5, anticorps SMC-5, anticorps SMC5L1, anticorps MLZ-453, anticorps Smc5l1, anticorps mKIAA0594, anticorps mSMC5, anticorps structural maintenance of chromosomes 5, anticorps structural maintenance of chromosomes 5 S homeolog, anticorps SMC5, anticorps smc5, anticorps Smc5, anticorps smc5.S

Sujet:

Background: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).

Aliases: SMC5 antibody, KIAA0594 antibody, SMC5L1 antibody, Structural maintenance of chromosomes protein 5 antibody, SMC protein 5 antibody, SMC-5 antibody, hSMC5 antibody

UniProt: Q8IY18