SMC6 anticorps (AA 309-450) (Biotin)

N° du produit ABIN7170875

Détail du produit anti-SMC6 anticorps (Biotin)

Antigène: SMC6 (SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))

Épitope: AA 309-450

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMC6 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Structural maintenance of chromosomes protein 6 protein (309-450AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SMC6

Antigène: SMC6 (SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))

Autre désignation: SMC6 (SMC6 Produits)

Synonymes: anticorps SMC6L1, anticorps SMC-6, anticorps hSMC6, anticorps 2810489L22Rik, anticorps 3830418C19Rik, anticorps AA990493, anticorps AU018782, anticorps AW742439, anticorps Smc6l1, anticorps mKIAA4103, anticorps structural maintenance of chromosomes 6, anticorps SMC6, anticorps smc6, anticorps Smc6

Sujet:

Background: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).

Aliases: FLJ22116 antibody, FLJ35534 antibody, hSMC6 antibody, SMC 6 antibody, SMC protein 6 antibody, SMC-6 antibody, SMC6 antibody, SMC6 protein antibody, SMC6 structural maintenance of chromosomes 6 like 1 antibody, SMC6_HUMAN antibody, Smc6l1 antibody, Structural maintenance of chromosomes 6 antibody, Structural maintenance of chromosomes 6 like 1 antibody, Structural maintenance of chromosomes protein 6 antibody

UniProt: Q96SB8