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SUN2 anticorps (AA 45-155) (FITC)

SUN2 Reactivité: Humain Hôte: Lapin Polyclonal FITC
N° du produit ABIN7170977
  • Antigène Voir toutes SUN2 Anticorps
    SUN2 (Sad1 and UNC84 Domain Containing 2 (SUN2))
    Épitope
    • 7
    • 7
    • 7
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 45-155
    Reactivité
    • 42
    • 24
    • 22
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    Humain
    Hôte
    • 42
    Lapin
    Clonalité
    • 34
    • 8
    Polyclonal
    Conjugué
    • 16
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp SUN2 est conjugé à/à la FITC
    Application
    Veuillez nous consulter SVP
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human SUN domain-containing protein 2 protein (45-155AA)
    Isotype
    IgG
    Top Product
    Discover our top product SUN2 Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    SUN2 (Sad1 and UNC84 Domain Containing 2 (SUN2))
    Autre désignation
    SUN2 (SUN2 Produits)
    Synonymes
    anticorps UNC84B, anticorps B230369L08Rik, anticorps C030011B15, anticorps Unc84b, anticorps RGD1563141, anticorps Sad1 and UNC84 domain containing 2, anticorps SUN2, anticorps Sun2
    Sujet

    Background: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins, SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis, SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.

    Aliases: SUN2 antibody, FRIGG antibody, KIAA0668 antibody, RAB5IP antibody, UNC84B antibody, SUN domain-containing protein 2 antibody, Protein unc-84 homolog B antibody, Rab5-interacting protein antibody, Rab5IP antibody, Sad1/unc-84 protein-like 2 antibody

    UniProt
    Q9UH99
    Pathways
    Maintenance of Protein Location, SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2
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