SOCS5 anticorps (AA 1-270)

N° du produit ABIN7171007

Détail du produit anti-SOCS5 anticorps

Antigène: SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))

Épitope: AA 1-270

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOCS5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Suppressor of cytokine signaling 5 protein (1-270AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SOCS5

Antigène: SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))

Autre désignation: SOCS5 (SOCS5 Produits)

Synonymes: anticorps SOCS5, anticorps cis6, anticorps cish5, anticorps cish6, anticorps socs-5, anticorps GB18949, anticorps socs5, anticorps zgc:153506, anticorps CIS6, anticorps CISH6, anticorps Cish5, anticorps SOCS-5, anticorps 1810018L08Rik, anticorps mKIAA0671, anticorps RGD1564914, anticorps suppressor of cytokine signaling 5, anticorps suppressor of cytokine signaling 5a, anticorps suppressor of cytokine signaling 5 L homeolog, anticorps SOCS5, anticorps socs5, anticorps LOC552036, anticorps socs5a, anticorps Tsp_07018, anticorps socs5.L, anticorps Socs5

Sujet:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.

Aliases: SOCS5 antibody, CIS6 antibody, CISH5 antibody, CISH6 antibody, KIAA0671Suppressor of cytokine signaling 5 antibody, SOCS-5 antibody, Cytokine-inducible SH2 protein 6 antibody, CIS-6 antibody, Cytokine-inducible SH2-containing protein 5 antibody

UniProt: O75159

Pathways: Signalistation JAK/STAT, EGFR Signaling Pathway, Positive Regulation of Immune Effector Process