SMN1 anticorps (AA 3-194)

N° du produit ABIN7171024

Détail du produit anti-SMN1 anticorps

Antigène: SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))

Épitope: AA 3-194

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMN1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Survival motor neuron protein (3-194AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SMN1

Antigène: SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))

Autre désignation: SMN1 (SMN1 Produits)

Synonymes: anticorps SMN2, anticorps Smn, anticorps SMN, anticorps BCD541, anticorps GEMIN1, anticorps SMA, anticorps SMA1, anticorps SMA2, anticorps SMA3, anticorps SMA4, anticorps SMA@, anticorps SMNT, anticorps T-BCD541, anticorps TDRD16A, anticorps AI849087, anticorps Gemin1, anticorps SMN1, anticorps QtsA-10002, anticorps fa12d01, anticorps smn, anticorps wu:fa12d01, anticorps survival motor neuron protein, anticorps survival of motor neuron 1, telomeric, anticorps survival motor neuron 1, anticorps survival of motor neuron 2, centromeric, anticorps survival motor neuron protein-like, anticorps survival motor neuron, anticorps LOC461829, anticorps Smn1, anticorps SMN1, anticorps SMN2, anticorps LOC100348318, anticorps SMN, anticorps LOC100713418, anticorps LOC100065744, anticorps LOC102176643, anticorps smn1

Sujet:

Background: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).

Aliases: BCD541 antibody, Component of gems 1 antibody, Gemin 1 antibody, Gemin-1 antibody, OTTHUMP00000125198 antibody, OTTHUMP00000223567 antibody, OTTHUMP00000223568 antibody, OTTHUMP00000224066 antibody, OTTHUMP00000226924 antibody, SMA 1 antibody, SMA 2 antibody, SMA 3 antibody, SMA 4 antibody, SMA antibody, SMA@ antibody, SMA1 antibody, SMA2 antibody, SMA3 antibody, SMA4 antibody, SMN antibody, SMN_HUMAN antibody, SMN1 antibody, SMN2 antibody, SMNT antibody, Survival motor neuron protein antibody, Survival of motor neuron 1, telomeric antibody, T-BCD541 antibody

UniProt: Q16637

Pathways: Ribonucleoprotein Complex Subunit Organization