SMARCC2 anticorps (AA 300-650)
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- Antigène Voir toutes SMARCC2 Anticorps
- SMARCC2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily C, Member 2 (SMARCC2))
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Épitope
- AA 300-650
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SMARCC2 est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)
- Réactivité croisée
- Humain
- Purification
- Antigen Affinity Purified
- Immunogène
- Recombinant Human SWI/SNF complex subunit SMARCC2 protein (300-650AA)
- Isotype
- IgG
- Top Product
- Discover our top product SMARCC2 Anticorps primaire
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- Indications d'application
- Recommended dilution: IHC:1:20-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- SMARCC2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily C, Member 2 (SMARCC2))
- Autre désignation
- SMARCC2 (SMARCC2 Produits)
- Synonymes
- anticorps MGC80068, anticorps BAF170, anticorps CRACC2, anticorps Rsc8, anticorps 5930405J04Rik, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 L homeolog, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2, anticorps SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2, anticorps smarcc2.L, anticorps SMARCC2, anticorps smarcc2, anticorps Smarcc2
- Sujet
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Background: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth
Aliases: BAF 170 antibody, BAF170 antibody, BRG1 associated factor 170 antibody, BRG1-associated factor 170 antibody, Chromatin remodeling complex BAF170 subunit antibody, CRACC 2 antibody, CRACC2 antibody, Mammalian chromatin remodeling complex BRG1 associated factor 170 antibody, Rsc 8 antibody, Rsc8 antibody, SMARCC 2 antibody, Smarcc2 antibody, SMRC2_HUMAN antibody, SWI/SNF complex 170 kDa subunit antibody, SWI/SNF complex subunit SMARCC2 antibody, SWI/SNF related matrix associated actin dependent regulator of chromatin c2 antibody, SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 2 antibody, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 antibody, SWI3 like protein antibody
- UniProt
- Q8TAQ2
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