TNKS anticorps (AA 35-130) (HRP)

N° du produit ABIN7171499

Détail du produit anti-TNKS anticorps (HRP)

Antigène: TNKS (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS))

Épitope: AA 35-130

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNKS est conjugé à/à la HRP

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Tankyrase-1 protein (35-130AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TNKS

Antigène: TNKS (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS))

Autre désignation: TNKS (TNKS Produits)

Synonymes: anticorps wu:fe02c12, anticorps ARTD5, anticorps PARP-5a, anticorps PARP5A, anticorps PARPL, anticorps TIN1, anticorps TINF1, anticorps TNKS1, anticorps pART5, anticorps 4930554K12Rik, anticorps AI662855, anticorps C86528, anticorps D130072O21Rik, anticorps TANK1, anticorps mTNKS1, anticorps tankyrase-1, anticorps tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b, anticorps tankyrase, anticorps tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase, anticorps tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 S homeolog, anticorps tnksb, anticorps TNKS, anticorps Tnks, anticorps tnks2.S

Sujet:

Background: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.

Aliases: ADP-ribosyltransferase diphtheria toxin-like 5 antibody, OTTHUMP00000115550 antibody, OTTHUMP00000224675 antibody, PARP 5a antibody, PARP5A antibody, PARPL antibody, pART5 antibody, Poly [ADP-ribose] polymerase 5A antibody, TANK 1 antibody, TANK1 antibody, Tankyrase 1 antibody, Tankyrase I antibody, Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase antibody, Tankyrase-1 antibody, Tankyrase1 antibody, TankyraseI antibody, TIN 1 antibody, TIN1 antibody, TINF 1 antibody, TINF1 antibody, TNKS 1 antibody, TNKS antibody, TNKS-1 antibody, TNKS1 antibody, TNKS1_HUMAN antibody, TRF1 interacting ankyrin related ADP ribose polymerase antibody, TRF1-interacting ankyrin-related ADP-ribose polymerase antibody

UniProt: O95271