TNKS2 anticorps (AA 1-246)

N° du produit ABIN7171500

Détail du produit anti-TNKS2 anticorps

Antigène: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Épitope: AA 1-246

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNKS2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Tankyrase-2 protein (1-246AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TNKS2

Antigène: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Autre désignation: TNKS2 (TNKS2 Produits)

Synonymes: anticorps ARTD6, anticorps PARP-5b, anticorps PARP-5c, anticorps PARP5B, anticorps PARP5C, anticorps TANK2, anticorps TNKL, anticorps pART6, anticorps 5430432P15Rik, anticorps AA517131, anticorps AI662480, anticorps TNKS-2, anticorps Tank2, anticorps tankyrase-2, anticorps TNKS2, anticorps tankyrase-1, anticorps tnks, anticorps tnks.L, anticorps tnks2, anticorps tankyrase 2, anticorps tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, anticorps tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase S homeolog, anticorps TNKS2, anticorps Tnks2, anticorps tnks2, anticorps tnks.S

Sujet:

Background: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.

Aliases: ADP-ribosyltransferase diphtheria toxin-like 6 antibody, ARTD6 antibody, PARP 5b antibody, PARP 5c antibody, PARP-5b antibody, PARP-5c antibody, PARP5B antibody, PARP5C antibody, pART6 antibody, Poly [ADP ribose] polymerase 5B antibody, Poly [ADP-ribose] polymerase 5B antibody, TANK2 antibody, Tankyrase 2 antibody, Tankyrase II antibody, Tankyrase like protein antibody, Tankyrase related protein antibody, Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase 2 antibody, Tankyrase-2 antibody, Tankyrase-like protein antibody, Tankyrase-related protein antibody, TNKL antibody, TNKS 2 antibody, TNKS-2 antibody, TNKS2 antibody, TNKS2_HUMAN antibody, TRF1 Interacting Ankyrin Related ADP ribose polymerase 2 antibody, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 antibody

UniProt: Q9H2K2