TRF2 anticorps (AA 78-238)

N° du produit ABIN7171733

Détail du produit anti-TRF2 anticorps

Antigène: TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

Épitope: AA 78-238

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRF2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Telomeric repeat-binding factor 2 protein (78-238AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TRF2

Antigène: TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

Autre désignation: TERF2 (TERF2 Produits)

Synonymes: anticorps TERF2, anticorps TRBF2, anticorps TRF2, anticorps trf2, anticorps telomeric repeat binding factor 2, anticorps telomeric repeat binding factor 2 L homeolog, anticorps TERF2, anticorps Terf2, anticorps terf2.L

Sujet:

Background: Binds the telomeric double-stranded 5\\\'-TTAGGG-3\\\' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5\\\'-TTAGGG-3\\\' repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3\\\' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.

Aliases: Telomeric DNA binding protein antibody, Telomeric DNA-binding protein antibody, Telomeric repeat binding factor 2 antibody, Telomeric repeat binding protein 2 antibody, Telomeric repeat-binding factor 2 antibody, TERF 2 antibody, Terf2 antibody, TERF2_HUMAN antibody, TRBF 2 antibody, TRBF2 antibody, TRF 2 antibody, TRF2 antibody, TTAGGG repeat binding factor 2 antibody, TTAGGG repeat-binding factor 2 antibody

UniProt: Q15554

Pathways: Cycle Cellulaire, Telomere Maintenance