Tenascin R anticorps (AA 1231-1319)

N° du produit ABIN7171750

Détail du produit anti-Tenascin R anticorps

Antigène: Tenascin R (TNR) (Tenascin R (Restrictin, Janusin) (TNR))

Épitope: AA 1231-1319

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tenascin R est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Tenascin-R protein (1231-1319AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:500-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Tenascin R

Antigène: Tenascin R (TNR) (Tenascin R (Restrictin, Janusin) (TNR))

Autre désignation: TNR (TNR Produits)

Synonymes: anticorps TN-R, anticorps J1-tenascin, anticorps janusin, anticorps restrictin, anticorps J1NRM, anticorps tenascin R, anticorps TNR, anticorps Tnr

Sujet:

Background: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity).

Aliases: Janusin antibody, MGC149328 antibody, Restrictin antibody, Tenascin R (restrictin, janusin) antibody, Tenascin-R antibody, TENR_HUMAN antibody, TN-R antibody, Tnr antibody

UniProt: Q92752

Pathways: Regulation of Cell Size