TSPAN12 anticorps (AA 111-224)

N° du produit ABIN7171846

Détail du produit anti-TSPAN12 anticorps

Antigène: TSPAN12 (Tetraspanin 12 (TSPAN12))

Épitope: AA 111-224

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSPAN12 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Tetraspanin-12 protein (111-224AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TSPAN12

Antigène: TSPAN12 (Tetraspanin 12 (TSPAN12))

Autre désignation: TSPAN12 (TSPAN12 Produits)

Synonymes: anticorps tm4sf12, anticorps zgc:63880, anticorps EVR5, anticorps NET-2, anticorps NET2, anticorps TM4SF12, anticorps 9030619E17, anticorps AI426782, anticorps AI663988, anticorps AW111457, anticorps Tm4sf12, anticorps tetraspanin-7, anticorps tetraspanin 12, anticorps LOC412465, anticorps TSPAN12, anticorps tspan12, anticorps Tspan12

Sujet:

Background: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Aliases: TSPAN12 antibody, NET2 antibody, TM4SF12 antibody, UNQ774/PRO1568Tetraspanin-12 antibody, Tspan-12 antibody, Tetraspan NET-2 antibody, Transmembrane 4 superfamily member 12 antibody

UniProt: O95859