THOC1 anticorps (AA 428-657)

N° du produit ABIN7172050

Détail du produit anti-THOC1 anticorps

Antigène: THOC1 (THO Complex 1 (THOC1))

Épitope: AA 428-657

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp THOC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)

Réactivité croisée: Humain, Souris

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human THO complex subunit 1 protein (428-657AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur THOC1

Antigène: THOC1 (THO Complex 1 (THOC1))

Autre désignation: THOC1 (THOC1 Produits)

Synonymes: anticorps p84, anticorps MGC114861, anticorps Tho1, anticorps THOC1, anticorps Hpr1, anticorps HPR1, anticorps P84, anticorps P84N5, anticorps 3110002N20Rik, anticorps AW107452, anticorps NMP-84, anticorps LRRGT00070, anticorps THO complex 1, anticorps THO complex 1 protein L homeolog, anticorps THO complex subunit 1, anticorps THO complex 1 protein, anticorps thoc1, anticorps thoc1.L, anticorps THOC1, anticorps LOC100123388, anticorps Thoc1

Sujet:

Background: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5\\\' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi\\\'s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation. Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.

Aliases: hTREX84 antibody, Death domain containing protein p84N5 antibody, HPR 1 antibody, HPR1 antibody, hTREX84 antibody, Nuclear matrix protein p84 antibody, P84 antibody, p84N5 antibody, Tho 1 antibody, THO complex 1 antibody, THO complex subunit 1 antibody, Tho1 antibody, THOC 1 antibody, Thoc1 antibody, THOC1_HUMAN antibody

UniProt: Q96FV9