TREX1 anticorps (AA 1-270)
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- Antigène Voir toutes TREX1 Anticorps
- TREX1 (three Prime Repair Exonuclease 1 (TREX1))
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Épitope
- AA 1-270
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TREX1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Réactivité croisée
- Humain
- Purification
- Antigen Affinity Purified
- Immunogène
- Recombinant Human Three-prime repair exonuclease 1 protein (1-270AA)
- Isotype
- IgG
- Top Product
- Discover our top product TREX1 Anticorps primaire
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- Indications d'application
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- TREX1 (three Prime Repair Exonuclease 1 (TREX1))
- Autre désignation
- TREX1 (TREX1 Produits)
- Sujet
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Background: Major cellular 3\\\'-to-5\\\' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3\\\' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3\\\' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Aliases: TREX1 antibody, Three-prime repair exonuclease 1 antibody, EC 3.1.11.2 antibody, 3'-5' exonuclease TREX1 antibody, Deoxyribonuclease III antibody, DNase III antibody
- UniProt
- Q9NSU2
- Pathways
- Apoptose
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