TRAF2 anticorps (AA 147-281)

N° du produit ABIN7172232

Détail du produit anti-TRAF2 anticorps

Antigène: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Épitope: AA 147-281

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRAF2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human TNF receptor-associated factor 2 protein (147-281AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TRAF2

Antigène: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Autre désignation: TRAF2 (TRAF2 Produits)

Synonymes: anticorps MGC:45012, anticorps TRAP, anticorps TRAP3, anticorps TANK, anticorps AI325259, anticorps TNF-receptor-associated factor 2, anticorps conjugal transfer protein TraF, anticorps TNF receptor associated factor 2, anticorps TNF receptor-associated factor 2, anticorps Tnf receptor-associated factor 2, anticorps LOC661716, anticorps traF2, anticorps TRAF2, anticorps Traf2

Sujet:

Background: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes \'Lys-63\'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation, this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.

Aliases: E3 ubiquitin-protein ligase TRAF2 antibody, MGC:45012 antibody, OTTHUMP00000022625 antibody, OTTHUMP00000064745 antibody, TNF receptor associated factor 2 antibody, TNF receptor-associated factor 2 antibody, TNF receptor-associated protein antibody, TRAF 2 antibody, TRAF2 antibody, TRAF2_HUMAN antibody, TRAP 3 antibody, TRAP antibody, TRAP3 antibody, Tumor necrosis factor type 2 receptor associated protein 3 antibody, Tumor necrosis factor type 2 receptor-associated protein 3 antibody

UniProt: Q12933

Pathways: Signalisation NF-kappaB, Apoptose, Caspase Cascade in Apoptosis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteins