MAFB anticorps (AA 168-323) (Biotin)

N° du produit ABIN7172579

Détail du produit anti-MAFB anticorps (Biotin)

Antigène: MAFB (Transcription Factor MafB (MAFB))

Épitope: AA 168-323

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAFB est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Transcription factor MafB protein (168-323AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MAFB

Antigène: MAFB (Transcription Factor MafB (MAFB))

Autre désignation: MAFB (MAFB Produits)

Synonymes: anticorps MAFB, anticorps krml, anticorps Maf-B, anticorps XMafB, anticorps kreisler, anticorps MGC108453, anticorps valentino, anticorps KRML, anticorps MCTO, anticorps Krml, anticorps b-maf, anticorps kr, anticorps mafb, anticorps val, anticorps wu:fc22d11, anticorps wu:fj82a09, anticorps Kreisler, anticorps Krml1, anticorps MAF bZIP transcription factor B, anticorps v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B, anticorps v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B S homeolog, anticorps v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba, anticorps v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian), anticorps MAFB, anticorps mafb, anticorps mafb.S, anticorps Mafb, anticorps mafba

Sujet:

Background: Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.

Aliases: Kreisler antibody, Kreisler (mouse) maf related leucine zipper homolog antibody, Kreisler maf related leucine zipper homolog antibody, KRML antibody, MAF bZIP transcription factor B antibody, Maf-B antibody, Mafb antibody, MAFB/Kreisler basic region/leucine zipper transcription factor antibody, MAFB_HUMAN antibody, MGC43127 antibody, Segmentation protein KR antibody, Transcription factor MafB antibody, V maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) antibody, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B antibody

UniProt: Q9Y5Q3