YAP1 anticorps (AA 155-504)

N° du produit ABIN7172751

Détail du produit anti-YAP1 anticorps

Antigène: YAP1 (Yes-Associated Protein 1 (YAP1))

Épitope: AA 155-504

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp YAP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Transcriptional coactivator YAP1 protein (155-504AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IF:1:100-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur YAP1

Antigène: YAP1 (Yes-Associated Protein 1 (YAP1))

Autre désignation: YAP1 (YAP1 Produits)

Synonymes: anticorps YAP, anticorps YAP2, anticorps YAP65, anticorps YKI, anticorps xyap, anticorps yap, anticorps yap2, anticorps yap65, anticorps yki, anticorps AI325207, anticorps Yap, anticorps Yap65, anticorps Yki, anticorps Yorkie, anticorps cb194, anticorps sb:cb194, anticorps si:ch211-181p1.5, anticorps si:dkey-3b8.3, anticorps wu:fc18c04, anticorps zgc:158380, anticorps Yes associated protein 1, anticorps Yes associated protein 1 S homeolog, anticorps yes-associated protein 1, anticorps Yes-associated protein 1, anticorps YAP1, anticorps yap1.S, anticorps Yap1, anticorps yap1

Sujet:

Background: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750).

Aliases: 65 kDa Yes associated protein antibody, 65 kDa Yes-associated protein antibody, COB1 antibody, YAp 1 antibody, YAP 65 antibody, YAP antibody, YAP-1 antibody, YAP1 antibody, YAP1_HUMAN antibody, YAP2 antibody, YAP65 antibody, yes -associated protein delta antibody, Yes associated protein 1 65 kDa antibody, Yes associated protein 1 antibody, Yes associated protein 2 antibody, yes associated protein beta antibody, YKI antibody, Yorkie homolog antibody

UniProt: P46937

Pathways: Signalisation MAPK, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha