TMEM64 anticorps (AA 40-118)

N° du produit ABIN7173257

Détail du produit anti-TMEM64 anticorps

Antigène: TMEM64 (Transmembrane Protein 64 (TMEM64))

Épitope: AA 40-118

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMEM64 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Transmembrane protein 64 protein (40-118AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TMEM64

Antigène: TMEM64 (Transmembrane Protein 64 (TMEM64))

Autre désignation: TMEM64 (TMEM64 Produits)

Synonymes: anticorps 9630015D15Rik, anticorps AI790744, anticorps AV300874, anticorps transmembrane protein 64, anticorps TMEM64, anticorps Tmem64

Sujet:

Background: Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.

Aliases: TMEM64 antibody, TMM64_HUMAN antibody, Transmembrane protein 64 antibody

UniProt: Q6YI46