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TMEM64 anticorps (AA 40-118) (Biotin)

TMEM64 Reactivité: Humain ELISA Hôte: Lapin Polyclonal Biotin
N° du produit ABIN7173258
  • Antigène Tous les produits TMEM64
    TMEM64 (Transmembrane Protein 64 (TMEM64))
    Épitope
    AA 40-118
    Reactivité
    • 5
    • 1
    Humain
    Hôte
    • 5
    Lapin
    Clonalité
    • 5
    Polyclonal
    Conjugué
    • 2
    • 2
    • 1
    Cet anticorp TMEM64 est conjugé à/à la Biotin
    Application
    • 4
    • 2
    • 2
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Transmembrane protein 64 protein (40-118AA)
    Isotype
    IgG
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    TMEM64 (Transmembrane Protein 64 (TMEM64))
    Autre désignation
    TMEM64 (TMEM64 Produits)
    Synonymes
    anticorps 9630015D15Rik, anticorps AI790744, anticorps AV300874, anticorps transmembrane protein 64, anticorps TMEM64, anticorps Tmem64
    Sujet

    Background: Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.

    Aliases: TMEM64 antibody, TMM64_HUMAN antibody, Transmembrane protein 64 antibody

    UniProt
    Q6YI46
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