TRIB1 anticorps (AA 3-91) (Biotin)

N° du produit ABIN7375909

Détail du produit anti-TRIB1 anticorps (Biotin)

Antigène: TRIB1 (Tribbles Homolog 1 (TRIB1))

Épitope: AA 3-91

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIB1 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Tribbles homolog 1 protein (3-91AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TRIB1

Antigène: TRIB1 (Tribbles Homolog 1 (TRIB1))

Autre désignation: TRIB1 (TRIB1 Produits)

Synonymes: anticorps TRIB1, anticorps c8fw, anticorps gig2, anticorps skip1, anticorps trb1, anticorps tribbles, anticorps C8FW, anticorps GIG2, anticorps SKIP1, anticorps TRB1, anticorps A530090O15Rik, anticorps TRB-1, anticorps Trb1, anticorps Gig2, anticorps tribbles pseudokinase 1, anticorps tribbles pseudokinase 1 L homeolog, anticorps tribbles homolog 1 (Drosophila), anticorps TRIB1, anticorps trib1, anticorps trib1.L, anticorps Trib1

Sujet:

Background: Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase (PubMed:27041596). The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).

Aliases: C8FW antibody, G-protein-coupled receptor-induced gene 2 protein antibody, GIG-2 antibody, GIG2 antibody, SKIP1 antibody, TRB-1 antibody, TRB1 antibody, Trib1 antibody, TRIB1_HUMAN antibody, Tribbles homolog 1 antibody

UniProt: Q96RU8

Pathways: Smooth Muscle Cell Migration