TBCD anticorps (AA 2-96)

N° du produit ABIN7173750

Détail du produit anti-TBCD anticorps

Antigène: TBCD (Tubulin Folding Cofactor D (TBCD))

Épitope: AA 2-96

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBCD est non-conjugé

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Tubulin-specific chaperone D protein (2-96AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TBCD

Antigène: TBCD (Tubulin Folding Cofactor D (TBCD))

Autre désignation: TBCD (TBCD Produits)

Synonymes: anticorps SSD-1, anticorps tfcD, anticorps 2310057L06Rik, anticorps A030005L14Rik, anticorps mKIAA0988, anticorps tubulin folding cofactor D, anticorps tubulin-specific chaperone d, anticorps TBCD, anticorps Tbcd

Sujet:

Background: Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed:10722852, PubMed:10831612, PubMed:11847227, PubMed:20740604, PubMed:27666370, PubMed:28158450). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed:27666370). Involved in neuron morphogenesis (PubMed:27666374).

Aliases: Beta tubulin cofactor D antibody, Beta-tubulin cofactor D antibody, KIAA0988 antibody, SSD 1 antibody, SSD-1 antibody, SSD1 antibody, tbcd antibody, TBCD_HUMAN antibody, tfcD antibody, Tubulin folding cofactor D antibody, Tubulin specific chaperone D antibody, Tubulin-folding cofactor D antibody, Tubulin-specific chaperone D antibody

UniProt: Q9BTW9

Pathways: Cell-Cell Junction Organization