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TBCD anticorps (AA 2-96)

TBCD Reactivité: Humain ELISA, IF, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7173750
  • Antigène Voir toutes TBCD Anticorps
    TBCD (Tubulin Folding Cofactor D (TBCD))
    Épitope
    • 3
    • 2
    • 2
    • 1
    • 1
    AA 2-96
    Reactivité
    • 10
    • 2
    • 1
    Humain
    Hôte
    • 9
    • 2
    Lapin
    Clonalité
    • 11
    Polyclonal
    Conjugué
    • 8
    • 1
    • 1
    • 1
    Cet anticorp TBCD est non-conjugé
    Application
    • 8
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Tubulin-specific chaperone D protein (2-96AA)
    Isotype
    IgG
  • Indications d'application
    Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    TBCD (Tubulin Folding Cofactor D (TBCD))
    Autre désignation
    TBCD (TBCD Produits)
    Synonymes
    anticorps SSD-1, anticorps tfcD, anticorps 2310057L06Rik, anticorps A030005L14Rik, anticorps mKIAA0988, anticorps tubulin folding cofactor D, anticorps tubulin-specific chaperone d, anticorps TBCD, anticorps Tbcd
    Sujet

    Background: Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed:10722852, PubMed:10831612, PubMed:11847227, PubMed:20740604, PubMed:27666370, PubMed:28158450). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed:27666370). Involved in neuron morphogenesis (PubMed:27666374).

    Aliases: Beta tubulin cofactor D antibody, Beta-tubulin cofactor D antibody, KIAA0988 antibody, SSD 1 antibody, SSD-1 antibody, SSD1 antibody, tbcd antibody, TBCD_HUMAN antibody, tfcD antibody, Tubulin folding cofactor D antibody, Tubulin specific chaperone D antibody, Tubulin-folding cofactor D antibody, Tubulin-specific chaperone D antibody

    UniProt
    Q9BTW9
    Pathways
    Cell-Cell Junction Organization
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