HCK anticorps (AA 1-220)

N° du produit ABIN7174029

Détail du produit anti-HCK anticorps

Antigène: HCK (Hemopoietic Cell Kinase (HCK))

Épitope: AA 1-220

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HCK est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Tyrosine-protein kinase HCK protein (1-220AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur HCK

Antigène: HCK (Hemopoietic Cell Kinase (HCK))

Autre désignation: HCK (HCK Produits)

Synonymes: anticorps laloo, anticorps HCK, anticorps MGC107870, anticorps JTK9, anticorps p59Hck, anticorps p61Hck, anticorps AI849071, anticorps Bmk, anticorps Hctk, anticorps p56Hck, anticorps HCK proto-oncogene, Src family tyrosine kinase L homeolog, anticorps HCK proto-oncogene, Src family tyrosine kinase, anticorps hemopoietic cell kinase, anticorps hck.L, anticorps HCK, anticorps hck, anticorps Hck

Sujet:

Background: Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.

Aliases: Bmk antibody, Hck 1 antibody, Hck antibody, HCK_HUMAN antibody, Hemopoietic cell kinase antibody, JTK9 antibody, p59-HCK/p60-HCK antibody, p59Hck antibody, p59HCK/p60HCK antibody, p61Hck antibody, Tyrosine protein kinase HCK antibody, Tyrosine-protein kinase HCK antibody

UniProt: P08631

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling