TYRO3 anticorps (AA 728-873)

N° du produit ABIN7174052

Détail du produit anti-TYRO3 anticorps

Antigène: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Épitope: AA 728-873

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TYRO3 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Tyrosine-protein kinase receptor TYRO3 protein (728-873AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TYRO3

Antigène: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Autre désignation: TYRO3 (TYRO3 Produits)

Synonymes: anticorps TYRO3, anticorps brt, anticorps byk, anticorps dtk, anticorps rse, anticorps sky, anticorps tif, anticorps Xksy, anticorps MGC145734, anticorps DKFZp469I0432, anticorps LOC100231598, anticorps BYK, anticorps Dtk, anticorps RSE, anticorps Sky, anticorps Tif, anticorps Brt, anticorps REK, anticorps ksy, anticorps xksy, anticorps AI323366, anticorps Etk-2, anticorps Rse, anticorps TYRO3 protein tyrosine kinase, anticorps TYRO3 protein tyrosine kinase L homeolog, anticorps TYRO3 protein tyrosine kinase 3, anticorps TYRO3, anticorps tyro3, anticorps Tyro3, anticorps tyro3.L

Sujet:

Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Aliases: Brt antibody, BYK antibody, DTK antibody, Etk-2 antibody, protein tyrosine kinase 3 antibody, Rek antibody, RSE antibody, SKY antibody, Tif antibody, tyro3 antibody, TYRO3 protein tyrosine kinase antibody, TYRO3_HUMAN antibody, Tyrosine-protein kinase byk antibody, Tyrosine-protein kinase DTK antibody, Tyrosine-protein kinase receptor TYRO3 antibody, Tyrosine-protein kinase RSE antibody, Tyrosine-protein kinase SKY antibody, Tyrosine-protein kinase TIF antibody

UniProt: Q06418

Pathways: Signalisation RTK