AXL anticorps (AA 312-447)

N° du produit ABIN7174056

Détail du produit anti-AXL anticorps

Antigène: AXL (AXL Receptor tyrosine Kinase (AXL))

Épitope: AA 312-447

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AXL est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Tyrosine-protein kinase receptor UFO protein (312-447AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur AXL

Antigène: AXL (AXL Receptor tyrosine Kinase (AXL))

Autre désignation: AXL (AXL Produits)

Synonymes: anticorps JTK11, anticorps UFO, anticorps AI323647, anticorps Ark, anticorps Tyro7, anticorps Ufo, anticorps AXL receptor tyrosine kinase, anticorps Axl receptor tyrosine kinase, anticorps AXL, anticorps Axl

Sujet:

Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3, but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.

Aliases: Adhesion related kinase antibody, AI323647 antibody, Ark antibody, Axl antibody, AXL oncogene antibody, AXL receptor tyrosine kinase antibody, AXL transforming gene antibody, AXL transforming sequence/gene antibody, EC 2.7.10.1 antibody, JTK11 antibody, Oncogene AXL antibody, Tyro7 antibody, Tyrosine protein kinase receptor UFO antibody, Tyrosine-protein kinase receptor UFO antibody, UFO antibody, UFO_HUMAN antibody

UniProt: P30530

Pathways: Signalisation RTK, Cellular Response to Molecule of Bacterial Origin