Ubiquilin 1 anticorps (AA 1-300)

N° du produit ABIN7174224

Détail du produit anti-Ubiquilin 1 anticorps

Antigène: Ubiquilin 1 (UBQLN1)

Épitope: AA 1-300

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ubiquilin 1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Ubiquilin-1 protein (1-300AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Ubiquilin 1

Antigène: Ubiquilin 1 (UBQLN1)

Autre désignation: UBQLN1 (UBQLN1 Produits)

Synonymes: anticorps UBQLN1, anticorps DA41, anticorps DSK2, anticorps PLIC-1, anticorps UBQN, anticorps XDRP1, anticorps 1110046H03Rik, anticorps 1810030E05Rik, anticorps AU019746, anticorps C77538, anticorps D13Ertd372e, anticorps Da41, anticorps Dsk2, anticorps Plic-1, anticorps Plic1, anticorps Xdrp1, anticorps ubiquilin 1, anticorps UBQLN1, anticorps Ubqln1

Sujet:

Background: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Isoform 1, isoform 2 and isoform 3 play a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Involved in the regulation of macroautophagy and autophagosome formation, required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Isoform 1 and isoform 3 play a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently downregulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity).

Aliases: DA41 antibody, DSK2 antibody, FLJ90054 antibody, hPLIC-1 antibody, hPLIC1 antibody, PLIC-1 antibody, PLIC1 antibody, Protein linking IAP with cytoskeleton 1 antibody, Ubiquilin-1 antibody, Ubiquilin1 antibody, UBQL1_HUMAN antibody, UBQLN1 antibody, UBQN antibody, XDRP1 antibody

UniProt: Q9UMX0