USP2 anticorps (C-Term)

N° du produit ABIN7174279

Détail du produit anti-USP2 anticorps

Antigène: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Épitope: AA 200-430, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 2 protein (200-430AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur USP2

Antigène: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Autre désignation: USP2 (USP2 Produits)

Synonymes: anticorps UBP41, anticorps USP9, anticorps B930035K21Rik, anticorps Ubp41, anticorps UBP-t, anticorps UBP46, anticorps ubp52, anticorps ubp66, anticorps zgc:92134, anticorps ubiquitin specific peptidase 2, anticorps ubiquitin specific peptidase 2a, anticorps USP2, anticorps Usp2, anticorps usp2a

Sujet:

Background: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).

Aliases: 41 kDa ubiquitin specific protease antibody, 41 kDa ubiquitin-specific protease antibody, Deubiquitinating enzyme 2 antibody, Ubiquitin carboxyl terminal hydrolase 2 antibody, Ubiquitin carboxyl-terminal hydrolase 2 antibody, ubiquitin specific peptidase 2 antibody, Ubiquitin specific processing protease 2 antibody, Ubiquitin specific protease 12 antibody, Ubiquitin specific protease 9 antibody, Ubiquitin specific protease, 41kD antibody, Ubiquitin thioesterase 2 antibody, Ubiquitin thiolesterase 2 antibody, Ubiquitin-specific-processing protease 2 antibody, Ubiquitin-specific-processing protease testis antibody, UBP-t antibody, UBP2_HUMAN antibody, UBP41 antibody, USP2 antibody, USP9 antibody

UniProt: O75604