USP2 anticorps (C-Term) (HRP)

N° du produit ABIN7174287

Détail du produit anti-USP2 anticorps (HRP)

Antigène: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Épitope: AA 258-417, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP2 est conjugé à/à la HRP

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 20 protein (258-417AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur USP2

Antigène: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Autre désignation: USP2 (USP2 Produits)

Synonymes: anticorps UBP41, anticorps USP9, anticorps B930035K21Rik, anticorps Ubp41, anticorps UBP-t, anticorps UBP46, anticorps ubp52, anticorps ubp66, anticorps zgc:92134, anticorps ubiquitin specific peptidase 2, anticorps ubiquitin specific peptidase 2a, anticorps USP2, anticorps Usp2, anticorps usp2a

Sujet:

Background: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both \'Lys-48\'- and \'Lys-63\'-linked polyubiquitin chains.

Aliases: Deubiquitinating enzyme 20 antibody, hVDU2 antibody, KIAA1003 antibody, LSFR 3A antibody, LSFR3A antibody, pVHL interacting deubiquitinating enzyme 2 antibody, Ubiquitin carboxyl terminal hydrolase 20 antibody, Ubiquitin carboxyl-terminal hydrolase 20 antibody, ubiquitin specific peptidase 20 antibody, Ubiquitin specific processing protease 20 antibody, Ubiquitin specific protease 20 antibody, Ubiquitin thioesterase 20 antibody, Ubiquitin thiolesterase 20 antibody, Ubiquitin-specific-processing protease 20 antibody, UBP20_HUMAN antibody, USP 20 antibody, USP20 antibody, VDU 2 antibody, VDU2 antibody, VHL interacting deubiquitinating enzyme 2 antibody, VHL-interacting deubiquitinating enzyme 2 antibody

UniProt: Q9Y2K6