USP28 anticorps (AA 430-580)

N° du produit ABIN7174303

Détail du produit anti-USP28 anticorps

Antigène: USP28 (Ubiquitin Specific Peptidase 28 (USP28))

Épitope: AA 430-580

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP28 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 28 protein (430-580AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur USP28

Antigène: USP28 (Ubiquitin Specific Peptidase 28 (USP28))

Autre désignation: USP28 (USP28 Produits)

Synonymes: anticorps im:7138195, anticorps USP28, anticorps 9830148O20Rik, anticorps AU022237, anticorps mKIAA1515, anticorps ubiquitin specific peptidase 28, anticorps USP28, anticorps usp28, anticorps Usp28

Sujet:

Background: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306).

Aliases: Deubiquitinating enzyme 28 antibody, KIAA1515 antibody, Ubiquitin carboxyl terminal hydrolase 28 antibody, Ubiquitin carboxyl-terminal hydrolase 28 antibody, ubiquitin carboxyl-terminal hydrolase 28 variant 1 antibody, Ubiquitin specific peptidase 28 antibody, Ubiquitin specific processing protease 28 antibody, Ubiquitin specific protease 28 antibody, Ubiquitin thioesterase 28 antibody, Ubiquitin thiolesterase 28 antibody, Ubiquitin-specific-processing protease 28 antibody, UBP28_HUMAN antibody, USP 28 antibody, USP28 antibody, USP28 protein antibody

UniProt: Q96RU2