USP3 anticorps (C-Term)

N° du produit ABIN7174308

Détail du produit anti-USP3 anticorps

Antigène: USP3 (Ubiquitin Specific Peptidase 3 (USP3))

Épitope: AA 101-400, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 30 protein (101-400AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur USP3

Antigène: USP3 (Ubiquitin Specific Peptidase 3 (USP3))

Autre désignation: USP3 (USP3 Produits)

Synonymes: anticorps fe50h06, anticorps wu:fe50h06, anticorps USP3, anticorps SIH003, anticorps UBP, anticorps AA409661, anticorps BC017156, anticorps ubiquitin specific peptidase 3, anticorps ubiquitin specific peptidase 3 L homeolog, anticorps usp3, anticorps USP3, anticorps usp3.L, anticorps Usp3

Sujet:

Background: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin\\\'s ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves \\\'Lys-6\\\'- and \\\'Lys-11\\\'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at \\\'Ser-65\\\' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).

Aliases: Deubiquitinating enzyme 30 antibody, FLJ40511 antibody, Ub-specific protease 30 antibody, Ubiquitin carboxyl terminal hydrolase 30 antibody, Ubiquitin carboxyl-terminal hydrolase 30 antibody, Ubiquitin specific peptidase 30 antibody, Ubiquitin specific processing protease 30 antibody, Ubiquitin thioesterase 30 antibody, Ubiquitin thiolesterase 30 antibody, Ubiquitin-specific-processing protease 30 antibody, UBP30_HUMAN antibody, usp30 antibody

UniProt: Q70CQ3