FAM105B anticorps (AA 1-287)
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- Antigène Tous les produits FAM105B
- FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))
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Épitope
- AA 1-287
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FAM105B est non-conjugé
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Application
- ELISA, Immunofluorescence (IF)
- Réactivité croisée
- Humain
- Purification
- Antigen Affinity Purified
- Immunogène
- Recombinant Human Ubiquitin thioesterase otulin protein (1-287AA)
- Isotype
- IgG
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- Indications d'application
- Recommended dilution: IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- FAM105B (Family with Sequence Similarity 105, Member B (FAM105B))
- Autre désignation
- OTULIN (FAM105B Produits)
- Synonymes
- anticorps C79097, anticorps OTU deubiquitinase with linear linkage specificity, anticorps OTULIN, anticorps Otulin
- Sujet
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Background: Deubiquitinase that specifically removes linear (\'Met-1\'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327). Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:24726323, PubMed:24726327). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). Required for homeostasis of the LUBAC complex by restricting autoubiquination of the LUBAC complex subunit RNF31 (PubMed:24726323). Some results have suggested that OTULIN function is restricted to homeostasis of the LUBAC complex, because it is not stably associated with TNF or NOD2 receptor signaling complexes (RSCs) (PubMed:26670046). However, further report have shown that it plays active roles in receptor signaling (PubMed:26997266, PubMed:27523608). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a key role in innate immune response by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling (PubMed:23806334).
Aliases: AIPDS antibody, Deubiquitinating enzyme otulin antibody, F105B_HUMAN antibody, Fam105b antibody, Family with sequence similarity 105, member B antibody, FLJ34884 antibody, GUM antibody, OTU deubiquitinase with linear linkage specificity antibody, OTULIN antibody, Protein FAM105B antibody, Ubiquitin thioesterase Gumby antibody
- UniProt
- Q96BN8
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