ATG3 anticorps (AA 1-314)

N° du produit ABIN7174567

Détail du produit anti-ATG3 anticorps

Antigène: ATG3 (ATG3 Autophagy Related 3 (ATG3))

Épitope: AA 1-314

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Ubiquitin-like-conjugating enzyme ATG3 protein (1-314AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:1000-1:2000, IF:1:200-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ATG3

Antigène: ATG3 (ATG3 Autophagy Related 3 (ATG3))

Autre désignation: ATG3 (ATG3 Produits)

Synonymes: anticorps atg3, anticorps im:6910145, anticorps wu:fb15g12, anticorps zgc:64156, anticorps APG3, anticorps APG3-LIKE, anticorps APG3L, anticorps PC3-96, anticorps 2610016C12Rik, anticorps Apg3l, anticorps Atg3l, anticorps PIG-1, anticorps Pig1, anticorps ATATG3, anticorps K11J9.1, anticorps K11J9_1, anticorps autophagy related 3, anticorps autophagy 3 (APG3), anticorps similar to S. cerevisiae ATG3 (YNR007C) part of ubiquitin-like system that mediates Atg8-phosphatidylethanolamine conjugation required for protein-vacuolar targeting and autophagy, anticorps atg3, anticorps ATG3, anticorps Atg3

Sujet:

Background: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Aliases: 2610016C12Rik antibody, Apg 3 antibody, APG3 antibody, APG3 autophagy 3 like antibody, APG3 like antibody, APG3, S. cerevisiae, homolog of antibody, APG3-like antibody, APG3L antibody, Apg3p antibody, ATG 3 antibody, ATG3 antibody, ATG3 autophagy related 3 homolog antibody, ATG3 autophagy related 3 homolog (S. cerevisiae) antibody, ATG3_HUMAN antibody, Autophagy 3, S. cerevisiae, homolog of antibody, Autophagy Apg3p/Aut1p like antibody, autophagy related 3 antibody, Autophagy related protein 3 antibody, Autophagy-related protein 3 antibody, DKFZp564M1178 antibody, FLJ22125 antibody, hApg3 antibody, MGC15201 antibody, OTTHUMP00000214547 antibody, OTTHUMP00000214548 antibody, PC3 96 antibody, Protein PC3-96 antibody, Ubiquitin-like-conjugating enzyme ATG3 antibody

UniProt: Q9NT62

Pathways: Autophagy