UVSSA/KIAA1530 anticorps (AA 143-206) (Biotin)

N° du produit ABIN7175183

Détail du produit anti-UVSSA/KIAA1530 anticorps (Biotin)

Antigène: UVSSA/KIAA1530 (UVSSA) (UV Stimulated Scaffold Protein A (UVSSA))

Épitope: AA 143-206

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UVSSA/KIAA1530 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human UV-stimulated scaffold protein A protein (143-206AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur UVSSA/KIAA1530

Antigène: UVSSA/KIAA1530 (UVSSA) (UV Stimulated Scaffold Protein A (UVSSA))

Autre désignation: UVSSA (UVSSA Produits)

Synonymes: anticorps KIAA1530, anticorps UVSS3, anticorps kiaa1530, anticorps 4933407H18Rik, anticorps D330017J19Rik, anticorps Kiaa1530, anticorps mKIAA1530, anticorps UV stimulated scaffold protein A, anticorps UVSSA, anticorps uvssa, anticorps Uvssa

Sujet:

Background: Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.

Aliases: hypothetical protein LOC57654 antibody, K1530_HUMAN antibody, KIAA1530 antibody, Uncharacterized protein KIAA1530 antibody, UV stimulated scaffold protein A antibody, UVSS3 antibody, UVSSA antibody

UniProt: Q2YD98