VPS4A anticorps (AA 1-120)

N° du produit ABIN7175319

Détail du produit anti-VPS4A anticorps

Antigène: VPS4A (Vacuolar Protein Sorting-Associated Protein 4A (VPS4A))

Épitope: AA 1-120

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS4A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Réactivité croisée: Humain, Souris, Rat

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Vacuolar protein sorting-associated protein 4A protein (1-120AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur VPS4A

Antigène: VPS4A (Vacuolar Protein Sorting-Associated Protein 4A (VPS4A))

Autre désignation: VPS4A (VPS4A Produits)

Synonymes: anticorps vsp4, anticorps SKD1, anticorps SKD1A, anticorps SKD2, anticorps VPS4, anticorps VPS4-1, anticorps zgc:153907, anticorps 4930589C15Rik, anticorps AI325971, anticorps AW553189, anticorps vacuolar protein sorting 4 homolog A, anticorps vacuolar sorting protein 4, anticorps vacuolar protein sorting 4 homolog A L homeolog, anticorps vacuolar protein sorting 4a homolog A (S. cerevisiae), anticorps vacuolar protein sorting 4A, anticorps VPS4A, anticorps TP03_0351, anticorps vps4a, anticorps vps4a.L, anticorps Vps4a

Sujet:

Background: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission (PubMed:24814515). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Aliases: hVPS4 antibody, Protein SKD2 antibody, SKD1 antibody, SKD1 homolog antibody, SKD1A antibody, SKD2 antibody, Vacuolar protein sorting 4 homolog A antibody, Vacuolar protein sorting 4, yeast, homolog of, A antibody, Vacuolar protein sorting factor 4A antibody, Vacuolar protein sorting-associated protein 4A antibody, vacuolar sorting protein 4 antibody, VPS4 antibody, VPS4-1 antibody, Vps4a antibody, VPS4A_HUMAN antibody

UniProt: Q9UN37

Pathways: Dynamique des Microtubules, CXCR4-mediated Signaling Events