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WDR61 anticorps (AA 2-305) (FITC)

WDR61 Reactivité: Humain Hôte: Lapin Polyclonal FITC
N° du produit ABIN7175780
  • Antigène Voir toutes WDR61 Anticorps
    WDR61 (WD Repeat Domain 61 (WDR61))
    Épitope
    • 15
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    AA 2-305
    Reactivité
    • 37
    • 17
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 46
    • 6
    Lapin
    Clonalité
    • 48
    • 4
    Polyclonal
    Conjugué
    • 19
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp WDR61 est conjugé à/à la FITC
    Application
    Veuillez nous consulter SVP
     Réactivité croisée
    Humain
    Purification
    Antigen Affinity Purified
    Immunogène
    Recombinant Human WD repeat-containing protein 61 protein (2-305AA)
    Isotype
    IgG
    Top Product
    Discover our top product WDR61 Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    WDR61 (WD Repeat Domain 61 (WDR61))
    Autre désignation
    WDR61 (WDR61 Produits)
    Synonymes
    anticorps WDR61, anticorps REC14, anticorps SKI8, anticorps 2700038L12Rik, anticorps 2810418I05Rik, anticorps RGD1308228, anticorps WD repeat domain 61, anticorps Ski complex subunit Rec14, anticorps WD repeat domain 61 L homeolog, anticorps wdr61, anticorps WDR61, anticorps LOC692852, anticorps LOC732907, anticorps rec14, anticorps Wdr61, anticorps wdr61.L
    Sujet

    Background: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and \\\'Ser-2\\\'- and \\\'Ser-5\\\'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1, it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 \\\'Lys-4\\\' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of \\\'Lys-120\\\' of histone H2B (H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3\\\' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 \\\'Lys-4\\\' (H3K4me3), dimethylation on histone H3 \\\'Lys-79\\\' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.

    Aliases: Meiotic recombination REC14 protein homolog antibody, REC14 antibody, Recombination protein REC14 antibody, Ski8 antibody, SKI8 homolog antibody, WD repeat containing protein 61 antibody, WD repeat domain 61 antibody, WD repeat-containing protein 61 antibody, WDR 61 antibody, wdr61 antibody, WDR61_HUMAN antibody

    UniProt
    Q9GZS3
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